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Tissue Imaging/ Profiling; Prostate Cancer, Pancreatic Cancer, Breast Cancer, Cataracts, Arterial Stints, Polycystic Kidney Disease, Acute Kidney Disease, Cystic Fibrosis, & Liver Changes. Prostasomes & Exosomes; Specific to Prostate and Breast Cancer by Quantitative iTRAQ LC-MS/MS. Biomarker Discovery using Biological Fluids; from patients and animal models of; Pancreatic Cancer, Polycystic Kidney Disease, Prostate Cancer, Breast Cancer, Cervical Cancer, Dietary Studies. Affects of Dietary Fatty Acids on Cancer Progression; Quantitative Global Proteomic Studies in Established Prostate Cancer Cell Lines. Steroids as the Less Novel/ Novel Therapeutic; Studies in Established Prostate and Pancreatic Cell Lines using SILAC. Reversing the FFPE Crosslink; Quantitative Proteomics on Fixed Tissues as compared to adjacent Flash Frozen Samples, collaboration with Qiagen and Protein Discovery. Monitoring Degradation Products in Tissues; Programmed Proteolysis, and Oxidation, Relating to Post-Surgical Ischemia. Informatics & Systems Biology; Sashimi Project & Cytoscape, from the front to back end, identification of the unseen by virtue of connecting the dots, collaboration with Institutes for System Biology (ISB). Spectral Preprocessing & Statistical Analysis; Improving throughput and statistical strategies in the analysis of both MALDI MS profiles and of LCMS runs from biological fluids, cells in culture, and tissues. Collaborations with Genedata. |
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Finding a Cure Through Discovery Based Sciences |
Research Focuses |